New research indicates that people who stop using popular slimming jabs like Mounjaro or Wegovy may regain lost weight far faster than those who halt conventional diet and exercise regimens.
Published data in a leading medical journal points out that while obese individuals can lose a large proportion of their total mass while on the medication, the weight comes back at an estimated rate of nearly a kilo each month after stopping.
"Users purchasing these drugs should be cognizant of the danger of fast weight regain when the therapy ends," stated expert Dr. Susan Jebb.
That rate of recovery suggests a reversion to starting mass in about one and a half years.
Analyzing Therapies
The study, which looked at dozens of studies involving thousands of participants, compared the outcomes of GLP-1 agonists with conventional dieting.
Researchers point out that individuals who lose weight through diet and exercise usually see a slower creep back—approximately 100 grams monthly—after stopping.
The Reason for the Quick Rebound
Nutrition scientists believe the mode of action of the injections explains the accelerated regain.
The injections mimic a natural hormone called GLP-1, which controls hunger.
"Long-term administration of GLP-1 levels far above than the body's typical production may cause the body to produce less of its endogenous GLP-1, and may also reduce responsiveness to its actions," noted Dr. Adam Collins, a nutrition specialist.
"Withdrawal of this medication leads to hunger is no longer kept in check, making binge eating much more probable."
An Ongoing Disease?
Health authorities suggest the injections for people with obesity-related medical conditions, accompanied by recommended diet and exercise modifications.
Many experts argue that, considering the likelihood of weight regain, the treatment is often ongoing.
This opinion is supported by pharmaceutical companies, who state that the results "emphasize the persistent character of excess weight," similar to managing diseases like hypertension.
Patient Accounts
Users who have come off the jabs report a sudden resurgence of cravings.
"It was like a trigger that goes on and you're instantly ravenous," said one woman.
The struggle is exacerbated if patients have not developed permanent dietary or behavioural changes during therapy.
Growing Adoption
Figures show that a significant number of people in the UK have used these injections in the past year, with desire continuing to grow.
- Use is higher among women compared to males.
- The 40s and 50s demographic shows the highest level of interest.
- A large proportion obtain the drugs through private prescriptions rather than the NHS.
In conclusion, clinicians emphasize that while the jabs are potent agents for weight loss, they are not a standalone cure and lasting health benefits relies on combined lifestyle support.
